Blockade of Na/H exchanger stimulates glioma tumor immunogenicity and enhances combinatorial TMZ and anti-PD-1 therapy

The weak immunogenicity of gliomas presents a barrier for effective immunotherapy. Na/H exchanger isoform 1 (NHE1) maintains alkaline intracellular pH (pH(i)) of glioma cells and acidic microenvironment. In addition, NHE1 is expressed in tumor-associated microglia and tumor-associated macrophages (T...

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Publicado no:Cell Death Dis
Principais autores: Guan, Xiudong, Hasan, Md Nabiul, Begum, Gulnaz, Kohanbash, Gary, Carney, Karen E., Pigott, Victoria M., Persson, Anders I., Castro, Maria G., Jia, Wang, Sun, Dandan
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6160445/
https://ncbi.nlm.nih.gov/pubmed/30262908
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-018-1062-3
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