Flavin monooxygenase 3, the host hepatic enzyme in the metaorganismal trimethylamine N-oxide-generating pathway, modulates platelet responsiveness and thrombosis risk

BACKGROUND: Gut microbes play a critical role in the production of trimethylamine N-oxide (TMAO), an atherogenic metabolite that impacts platelet responsiveness and thrombosis potential. Involving both microbe and host enzymatic machinery, TMAO generation utilizes a metaorganismal pathway, beginning...

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Udgivet i:J Thromb Haemost
Main Authors: Zhu, W., Buffa, J. A., Wang, Z., Warrier, M., Schugar, R., Shih, D. M., Gupta, N., Gregory, J. C., Org, E., Fu, X., Li, L., DiDonato, J. A., Lusis, A. J., Brown, J. M., Hazen, S. L.
Format: Artigo
Sprog:Inglês
Udgivet: 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6156942/
https://ncbi.nlm.nih.gov/pubmed/29981269
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jth.14234
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