An orally bioavailable Chk1 inhibitor, CCT244747, sensitizes bladder and head and neck cancer cell lines to radiation

PURPOSE: Chk1 inhibition increases cell sensitivity to both chemotherapy and radiotherapy in several tumour types and is, therefore, a promising anti-cancer approach. Although several Chk1 inhibitors have been developed, their clinical progress has been hampered by low bioavailability and off-target...

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Bibliografiske detaljer
Udgivet i:Radiother Oncol
Main Authors: Patel, Radhika, Barker, Holly E., Kyula, Joan, McLaughlin, Martin, Dillon, Magnus T., Schick, Ulrike, Hafsi, Hind, Thompson, Alan, Khoo, Vincent, Harrington, Kevin, Zaidi, Shane
Format: Artigo
Sprog:Inglês
Udgivet: 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6155495/
https://ncbi.nlm.nih.gov/pubmed/28131548
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.radonc.2016.12.026
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