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Glycemic Variability Promotes Both Local Invasion and Metastatic Colonization by Pancreatic Ductal Adenocarcinoma

BACKGROUND & AIMS: Although nearly half of pancreatic ductal adenocarcinoma (PDAC) patients have diabetes mellitus with episodes of hyperglycemia, its tumor microenvironment is hypoglycemic. Thus, it is crucial for PDAC cells to develop adaptive mechanisms dealing with oscillating glucose levels...

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Bibliografiske detaljer
Udgivet i:Cell Mol Gastroenterol Hepatol
Main Authors: Jian, Ziying, Cheng, Tao, Zhang, Zhiheng, Raulefs, Susanne, Shi, Kuangyu, Steiger, Katja, Maeritz, Nadja, Kleigrewe, Karin, Hofmann, Thomas, Benitz, Simone, Bruns, Philipp, Lamp, Daniel, Jastroch, Martin, Akkan, Jan, Jäger, Carsten, Huang, Peilin, Nie, Shuang, Shen, Shanshan, Zou, Xiaoping, Ceyhan, Güralp O., Michalski, Christoph W., Friess, Helmut, Kleeff, Jörg, Kong, Bo
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2018
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6154439/
https://ncbi.nlm.nih.gov/pubmed/30258965
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jcmgh.2018.07.003
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