Glycemic Variability Promotes Both Local Invasion and Metastatic Colonization by Pancreatic Ductal Adenocarcinoma

BACKGROUND & AIMS: Although nearly half of pancreatic ductal adenocarcinoma (PDAC) patients have diabetes mellitus with episodes of hyperglycemia, its tumor microenvironment is hypoglycemic. Thus, it is crucial for PDAC cells to develop adaptive mechanisms dealing with oscillating glucose levels...

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Gepubliceerd in:Cell Mol Gastroenterol Hepatol
Hoofdauteurs: Jian, Ziying, Cheng, Tao, Zhang, Zhiheng, Raulefs, Susanne, Shi, Kuangyu, Steiger, Katja, Maeritz, Nadja, Kleigrewe, Karin, Hofmann, Thomas, Benitz, Simone, Bruns, Philipp, Lamp, Daniel, Jastroch, Martin, Akkan, Jan, Jäger, Carsten, Huang, Peilin, Nie, Shuang, Shen, Shanshan, Zou, Xiaoping, Ceyhan, Güralp O., Michalski, Christoph W., Friess, Helmut, Kleeff, Jörg, Kong, Bo
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Elsevier 2018
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Original Research
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6154439/
https://ncbi.nlm.nih.gov/pubmed/30258965
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jcmgh.2018.07.003
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