Glycemic Variability Promotes Both Local Invasion and Metastatic Colonization by Pancreatic Ductal Adenocarcinoma

BACKGROUND & AIMS: Although nearly half of pancreatic ductal adenocarcinoma (PDAC) patients have diabetes mellitus with episodes of hyperglycemia, its tumor microenvironment is hypoglycemic. Thus, it is crucial for PDAC cells to develop adaptive mechanisms dealing with oscillating glucose levels...

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Dades bibliogràfiques
Publicat a:Cell Mol Gastroenterol Hepatol
Autors principals: Jian, Ziying, Cheng, Tao, Zhang, Zhiheng, Raulefs, Susanne, Shi, Kuangyu, Steiger, Katja, Maeritz, Nadja, Kleigrewe, Karin, Hofmann, Thomas, Benitz, Simone, Bruns, Philipp, Lamp, Daniel, Jastroch, Martin, Akkan, Jan, Jäger, Carsten, Huang, Peilin, Nie, Shuang, Shen, Shanshan, Zou, Xiaoping, Ceyhan, Güralp O., Michalski, Christoph W., Friess, Helmut, Kleeff, Jörg, Kong, Bo
Format: Artigo
Idioma:Inglês
Publicat: Elsevier 2018
Matèries:
Original Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6154439/
https://ncbi.nlm.nih.gov/pubmed/30258965
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jcmgh.2018.07.003
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