Glycemic Variability Promotes Both Local Invasion and Metastatic Colonization by Pancreatic Ductal Adenocarcinoma

BACKGROUND & AIMS: Although nearly half of pancreatic ductal adenocarcinoma (PDAC) patients have diabetes mellitus with episodes of hyperglycemia, its tumor microenvironment is hypoglycemic. Thus, it is crucial for PDAC cells to develop adaptive mechanisms dealing with oscillating glucose levels...

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Pubblicato in:Cell Mol Gastroenterol Hepatol
Autori principali: Jian, Ziying, Cheng, Tao, Zhang, Zhiheng, Raulefs, Susanne, Shi, Kuangyu, Steiger, Katja, Maeritz, Nadja, Kleigrewe, Karin, Hofmann, Thomas, Benitz, Simone, Bruns, Philipp, Lamp, Daniel, Jastroch, Martin, Akkan, Jan, Jäger, Carsten, Huang, Peilin, Nie, Shuang, Shen, Shanshan, Zou, Xiaoping, Ceyhan, Güralp O., Michalski, Christoph W., Friess, Helmut, Kleeff, Jörg, Kong, Bo
Natura: Artigo
Lingua:Inglês
Pubblicazione: Elsevier 2018
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Original Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6154439/
https://ncbi.nlm.nih.gov/pubmed/30258965
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jcmgh.2018.07.003
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