Aldehydes are the predominant forces inducing DNA damage and inhibiting DNA repair in tobacco smoke carcinogenesis

Tobacco smoke (TS) contains numerous cancer-causing agents, with polycyclic aromatic hydrocarbons (PAHs) and nitrosamines being most frequently cited as the major TS human cancer agents. Many lines of evidence seriously question this conclusion. To resolve this issue, we determined DNA adducts induc...

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Bibliografiske detaljer
Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Weng, Mao-wen, Lee, Hyun-Wook, Park, Sung-Hyun, Hu, Yu, Wang, Hsing-Tsui, Chen, Lung-Chi, Rom, William N., Huang, William C., Lepor, Herbert, Wu, Xue-Ru, Yang, Chung S., Tang, Moon-shong
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2018
Fag:
PNAS Plus
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6142211/
https://ncbi.nlm.nih.gov/pubmed/29915082
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1804869115
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