Aldehydes are the predominant forces inducing DNA damage and inhibiting DNA repair in tobacco smoke carcinogenesis

Tobacco smoke (TS) contains numerous cancer-causing agents, with polycyclic aromatic hydrocarbons (PAHs) and nitrosamines being most frequently cited as the major TS human cancer agents. Many lines of evidence seriously question this conclusion. To resolve this issue, we determined DNA adducts induc...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Weng, Mao-wen, Lee, Hyun-Wook, Park, Sung-Hyun, Hu, Yu, Wang, Hsing-Tsui, Chen, Lung-Chi, Rom, William N., Huang, William C., Lepor, Herbert, Wu, Xue-Ru, Yang, Chung S., Tang, Moon-shong
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2018
Assuntos:
PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6142211/
https://ncbi.nlm.nih.gov/pubmed/29915082
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1804869115
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