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Binding modes of CYP106A2 redox partners determine differences in progesterone hydroxylation product patterns

Natural redox partners of bacterial cytochrome P450s (P450s) are mostly unknown. Therefore, substrate conversions are performed with heterologous redox partners; in the case of CYP106A2 from Bacillus megaterium ATCC 13368, bovine adrenodoxin (Adx) and adrenodoxin reductase (AdR). Our aim was to opti...

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Bibliographic Details
Published in:Commun Biol
Main Authors: Sagadin, Tanja, Riehm, Jan L., Milhim, Mohammed, Hutter, Michael C., Bernhardt, Rita
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2018
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6123783/
https://ncbi.nlm.nih.gov/pubmed/30271979
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s42003-018-0104-9
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