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The E3 ubiquitin ligase UBR5 regulates centriolar satellite stability and primary cilia

Primary cilia are crucial for signal transduction in a variety of pathways, including hedgehog and Wnt. Disruption of primary cilia formation (ciliogenesis) is linked to numerous developmental disorders (known as ciliopathies) and diseases, including cancer. The ubiquitin–proteasome system (UPS) com...

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Bibliographische Detailangaben
Veröffentlicht in:Mol Biol Cell
Hauptverfasser: Shearer, Robert F., Frikstad, Kari-Anne Myrum, McKenna, Jessie, McCloy, Rachael A., Deng, Niantao, Burgess, Andrew, Stokke, Trond, Patzke, Sebastian, Saunders, Darren N.
Format: Artigo
Sprache:Inglês
Veröffentlicht: The American Society for Cell Biology 2018
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6080653/
https://ncbi.nlm.nih.gov/pubmed/29742019
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E17-04-0248
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