Atomic-level evidence for packing and positional amyloid polymorphism by segment from TDP-43 RRM2

Proteins in the fibrous amyloid state are a major hallmark of neurodegenerative disease. Understanding the multiple conformations, or polymorphs, of amyloid proteins at the molecular level is a challenge of amyloid research. Here, we detail the wide range of polymorphs formed by a segment of human T...

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Publicado en:Nat Struct Mol Biol
Main Authors: Guenther, Elizabeth L., Ge, Peng, Trinh, Hamilton, Sawaya, Michael R., Cascio, Duilio, Boyer, David R., Gonen, Tamir, Zhou, Z. Hong, Eisenberg, David S.
Formato: Artigo
Idioma:Inglês
Publicado: 2018
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6056015/
https://ncbi.nlm.nih.gov/pubmed/29531287
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41594-018-0045-5
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