Gossypol Inhibits Non-small Cell Lung Cancer Cells Proliferation by Targeting EGFR(L858R/T790M)

Background: Overexpression of epidermal growth factor receptor (EGFR) has been reported to be implicated in the pathogenesis of non-small cell lung cancer (NSCLC). Several EGFR inhibitors have been used in clinical treatment of NSCLC, but the emergence of EGFR(L858R/T790M) resistant mutation has red...

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Vydáno v:Front Pharmacol
Hlavní autoři: Wang, Yuwei, Lai, Huanling, Fan, Xingxing, Luo, Lianxiang, Duan, Fugang, Jiang, Zebo, Wang, Qianqian, Leung, Elaine Lai Han, Liu, Liang, Yao, Xiaojun
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2018
Témata:
Pharmacology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6046546/
https://ncbi.nlm.nih.gov/pubmed/30038571
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2018.00728
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