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RNA Aptamers Rescue Mitochondrial Dysfunction in a Yeast Model of Huntington’s Disease
Huntington’s disease (HD) is associated with the misfolding and aggregation of mutant huntingtin harboring an elongated polyglutamine stretch at its N terminus. A distinguishing pathological hallmark of HD is mitochondrial dysfunction. Any strategy that can restore the integrity of the mitochondrial...
Gespeichert in:
| Veröffentlicht in: | Mol Ther Nucleic Acids |
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| Hauptverfasser: | , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
American Society of Gene & Cell Therapy
2018
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6023792/ https://ncbi.nlm.nih.gov/pubmed/30195782 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omtn.2018.04.010 |
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