Hierarchical analysis of RNA-seq reads improves the accuracy of allele-specific expression

MOTIVATION: Allele-specific expression (ASE) refers to the differential abundance of the allelic copies of a transcript. RNA sequencing (RNA-seq) can provide quantitative estimates of ASE for genes with transcribed polymorphisms. When short-read sequences are aligned to a diploid transcriptome, read...

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Detalhes bibliográficos
Publicado no:Bioinformatics
Main Authors: Raghupathy, Narayanan, Choi, Kwangbom, Vincent, Matthew J, Beane, Glen L, Sheppard, Keith S, Munger, Steven C, Korstanje, Ron, Pardo-Manual de Villena, Fernando, Churchill, Gary A
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2018
Assuntos:
Original Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6022640/
https://ncbi.nlm.nih.gov/pubmed/29444201
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/bioinformatics/bty078
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