Antileishmanial activity of sulphonamide nanoemulsions targeting the β-carbonic anhydrase from Leishmania species

The β-carbonic anhydrase (CA, EC 4.2.1.1) from Leishmania spp. (LdcCA) is effectively inhibited by aromatic/heterocyclic sulphonamides, in the low nanomolar range, but no in vitro antileishmanial activity was detected for such compounds. We formulated some of these sulphonamides as nanoemulsions (NE...

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Publicado en:J Enzyme Inhib Med Chem
Autores principales: da Silva Cardoso, Verônica, Vermelho, Alane Beatriz, Ricci Junior, Eduardo, Almeida Rodrigues, Igor, Mazotto, Ana Maria, Supuran, Claudiu T.
Formato: Artigo
Lenguaje:Inglês
Publicado: Taylor & Francis 2018
Materias:
Research Paper
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6010131/
https://ncbi.nlm.nih.gov/pubmed/29708476
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/14756366.2018.1463221
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