Novel [(3-indolylmethylene)hydrazono]indolin-2-ones as apoptotic anti-proliferative agents: design, synthesis and in vitro biological evaluation

On account of their significance as apoptosis inducing agents, merging indole and 3-hydrazinoindolin-2-one scaffolds is a logic tactic for designing pro-apoptotic agents. Consequently, 27 hybrids (6a–r, 9a–f and 11a–c) were synthesised and evaluated for their cytotoxicity against MCF-7, HepG-2 and H...

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Detalhes bibliográficos
Publicado no:J Enzyme Inhib Med Chem
Principais autores: Eldehna, Wagdy M., Abo-Ashour, Mahmoud F., Ibrahim, Hany S., Al-Ansary, Ghada H., Ghabbour, Hazem A., Elaasser, Mahmoud M., Ahmed, Hanaa Y. A., Safwat, Nesreen A.
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2018
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6010103/
https://ncbi.nlm.nih.gov/pubmed/29560733
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/14756366.2017.1421181
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