Synthesis and in vitro anti-proliferative activity of some novel isatins conjugated with quinazoline/phthalazine hydrazines against triple-negative breast cancer MDA-MB-231 cells as apoptosis-inducing agents

Treatment of patients with triple-negative breast cancer (TNBC) is challenging due to the absence of well- defined molecular targets and the heterogeneity of such disease. In our endeavor to develop potent isatin-based anti-proliferative agents, we utilized the hybrid-pharmacophore approach to synth...

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Detalhes bibliográficos
Publicado no:J Enzyme Inhib Med Chem
Main Authors: Eldehna, Wagdy M., Almahli, Hadia, Al-Ansary, Ghada H., Ghabbour, Hazem A., Aly, Mohamed H., Ismael, Omnia E., Al-Dhfyan, Abdullah, Abdel-Aziz, Hatem A.
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6010087/
https://ncbi.nlm.nih.gov/pubmed/28173708
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/14756366.2017.1279155
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