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Cationic polymers for non-viral gene delivery to human T cells

The clinical success of chimeric antigen receptor (CAR) T cell immunotherapy in treating multiple blood cancers has created a need for efficient methods of ex vivo gene delivery to primary human T cells for cell engineering. Here, we synthesize and evaluate a panel of cationic polymers for gene deli...

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Bibliographic Details
Published in:J Control Release
Main Authors: Olden, Brynn R., Cheng, Yilong, Yu, Jonathan L., Pun, Suzie H.
Format: Artigo
Language:Inglês
Published: 2018
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6008197/
https://ncbi.nlm.nih.gov/pubmed/29518467
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jconrel.2018.02.043
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