Lat(Y136F) knock-in mouse model for human IgG4-related disease

BACKGROUND: The adaptor protein Linker for activation of T cell (LAT) is a key signaling hub used by the T cell antigen receptor. Mutant mice expressing loss-of-function mutations affecting LAT and including a mutation in which tyrosine 136 is replaced by a phenylalanine (Lat(Y136F)) develop lymphop...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Yamada, Kazunori, Zuka, Masahiko, Ito, Kiyoaki, Mizuguchi, Keishi, Kakuchi, Yasushi, Onoe, Tamehito, Suzuki, Yasunori, Yamagishi, Masakazu, Izui, Shozo, Malissen, Marie, Malissen, Bernard, Kawano, Mitsuhiro
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2018
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6002065/
https://ncbi.nlm.nih.gov/pubmed/29902238
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0198417
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