Aerobic Glycolysis Is Essential for Normal Rod Function and Controls Secondary Cone Death in Retinitis Pigmentosa

Aerobic glycolysis accounts for ~80%–90% of glucose used by adult photoreceptors (PRs); yet, the importance of aerobic glycolysis for PR function or survival remains unclear. Here, we further established the role of aerobic glycolysis in murine rod and cone PRs. We show that loss of hexokinase-2 (HK...

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Udgivet i:Cell Rep
Main Authors: Petit, Lolita, Ma, Shan, Cipi, Joris, Cheng, Shun-Yun, Zieger, Marina, Hay, Nissim, Punzo, Claudio
Format: Artigo
Sprog:Inglês
Udgivet: 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5997286/
https://ncbi.nlm.nih.gov/pubmed/29847794
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2018.04.111
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