Diagnostic test accuracy of a 2-transcript host RNA signature for discriminating bacterial vs viral infection in febrile children

IMPORTANCE: As clinical features do not reliably distinguish bacterial from viral infection, many children worldwide receive unnecessary antibiotic treatment whilst bacterial infection is missed in others. OBJECTIVE: To identify a blood RNA expression signature that distinguishes bacterial from vira...

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Veröffentlicht in:JAMA
Hauptverfasser: Herberg, Jethro A, Kaforou, Myrsini, Wright, Victoria J, Shailes, Hannah, Eleftherohorinou, Hariklia, Hoggart, Clive J, Cebey-Lopez, Miriam, Carter, Michael J, Janes, Victoria A, Gormley, Stuart, Shimizu, Chisato, Tremoulet, Adriana H, Barendregt, Anouk M, Salas, Antonio, Kanegaye, John, Pollard, Andrew J, Faust, Saul N, Patel, Sanjay, Kuijpers, Taco, Martinon-Torres, Federico, Burns, Jane C, Coin, Lachlan JM, Levin, Michael
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2016
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5997174/
https://ncbi.nlm.nih.gov/pubmed/27552617
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1001/jama.2016.11236
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