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A computational framework for predicting obesity risk based on optimizing and integrating genetic risk score and gene expression profiles

Recent large-scale genome-wide association studies have identified tens of genetic loci robustly associated with Body Mass Index (BMI). Gene expression profiles were also found to be associated with BMI. However, accurate prediction of obesity risk utilizing genetic data remains challenging. In a co...

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Veröffentlicht in:PLoS One
Hauptverfasser: Joseph, Paule V., Wang, Yupeng, Fourie, Nicolaas H., Henderson, Wendy A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2018
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5993110/
https://ncbi.nlm.nih.gov/pubmed/29795655
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0197843
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