Atomic Structures of Segments from TDP-43 LCD and insight into Reversible and Pathogenic Aggregation

The normally soluble TAR DNA Binding Protein 43 (TDP-43) is found aggregated both in reversible stress granules and irreversible pathogenic amyloid. In TDP-43, the low complexity domain (LCD) is believed to be involved in both types of aggregation. To discover the structural origins of these two mod...

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Vydáno v:Nat Struct Mol Biol
Hlavní autoři: Guenther, Elizabeth L., Cao, Qin, Trinh, Hamilton, Lu, Jiahui, Sawaya, Michael R., Cascio, Duilio, Boyer, David R., Rodriguez, Jose A., Hughes, Michael P., Eisenberg, David S.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2018
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5990464/
https://ncbi.nlm.nih.gov/pubmed/29786080
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41594-018-0064-2
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