C5a Blockade Increases Regulatory T Cell Numbers and Protects Against Microvascular Loss and Epithelial Damage in Mouse Airway Allografts

Microvascular injury during acute rejection has been associated with massive infiltration of CD4(+) T effector cells, and the formation of complement products (C3a and C5a). Regulatory T cells (Tregs) are potent immunosuppressors of the adaptive immune system and have proven sufficient to rescue mic...

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Vydáno v:Front Immunol
Hlavní autoři: Khan, Mohammad Afzal, Alanazi, Fatimah, Ahmed, Hala Abdalrahman, Vater, Axel, Assiri, Abdullah Mohammed, Broering, Dieter Clemens
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2018
Témata:
Immunology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5976734/
https://ncbi.nlm.nih.gov/pubmed/29881374
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2018.01010
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