Synthesis, Characterization, and In Vitro and In Vivo Evaluations of 4-(N)-Docosahexaenoyl 2′, 2′-Difluorodeoxycytidine with Potent and Broad-Spectrum Antitumor Activity()()

In this study, a new compound, 4-(N)-docosahexaenoyl 2′, 2′-difluorodeoxycytidine (DHA-dFdC), was synthesized and characterized. Its antitumor activity was evaluated in cell culture and in mouse models of pancreatic cancer. DHA-dFdC is a poorly soluble, pale yellow waxy solid, with a molecular mass...

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Detalhes bibliográficos
Publicado no:Neoplasia
Main Authors: Naguib, Youssef W., Lansakara-P., Dharmika, Lashinger, Laura M., Rodriguez, B. Leticia, Valdes, Solange, Niu, Mengmeng, Aldayel, Abdulaziz M., Peng, Lan, Hursting, Stephen D., Cui, Zhengrong
Formato: Artigo
Idioma:Inglês
Publicado em: Neoplasia Press 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5965255/
https://ncbi.nlm.nih.gov/pubmed/26806350
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neo.2015.11.012
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