Total chemical synthesis of photoactivatable proteins for light-controlled manipulation of antigen–antibody interactions

We report the chemical synthesis of the first photo-activatable protein antigen that can be used to study antigen–antibody interaction mediated responses in B cells. This strategy facilitated fine tuning of the caged protein antigen to optimize its bioactivity and photochemical properties. One optim...

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Bibliografiske detaljer
Udgivet i:Chem Sci
Main Authors: Tang, Shan, Wan, Zhengpeng, Gao, Yiren, Zheng, Ji-Shen, Wang, Jing, Si, Yan-Yan, Chen, Xin, Qi, Hai, Liu, Lei, Liu, Wanli
Format: Artigo
Sprog:Inglês
Udgivet: Royal Society of Chemistry 2016
Fag:
Chemistry
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5965250/
https://ncbi.nlm.nih.gov/pubmed/29899912
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c5sc03404c
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