Basal cell carcinoma pathogenesis and therapy involving hedgehog signaling and beyond

Basal cell carcinoma (BCC) of the skin is driven by aberrant hedgehog signaling. Thus blocking this signaling pathway by small molecules such as vismodegib inhibits tumor growth. Primary cilium in the epidermal cells plays an integral role in the processing of hedgehog signaling-related proteins. Re...

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Udgivet i:Mol Carcinog
Main Authors: Bakshi, Anshika, Chaudhary, Sandeep C., Rana, Mehtab, Elmets, Craig A., Athar, Mohammad
Format: Artigo
Sprog:Inglês
Udgivet: 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5962346/
https://ncbi.nlm.nih.gov/pubmed/28574612
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/mc.22690
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