Increased HOXA5 expression provides a selective advantage for gain of whole chromosome 7 in IDH wild-type glioblastoma

Glioblastoma is the most frequently occurring and invariably fatal primary brain tumor in adults. The vast majority of glioblastomas is characterized by chromosomal copy number alterations, including gain of whole chromosome 7 and loss of whole chromosome 10. Gain of whole chromosome 7 is an early e...

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Detalhes bibliográficos
Publicado no:Genes Dev
Main Authors: Cimino, Patrick J., Kim, Youngmi, Wu, Hua-Jun, Alexander, Jes, Wirsching, Hans-Georg, Szulzewsky, Frank, Pitter, Ken, Ozawa, Tatsuya, Wang, Jiguang, Vazquez, Julio, Arora, Sonali, Rabadan, Raul, Levine, Ross, Michor, Franziska, Holland, Eric C.
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2018
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5959235/
https://ncbi.nlm.nih.gov/pubmed/29632085
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.312157.118
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