Increased HOXA5 expression provides a selective advantage for gain of whole chromosome 7 in IDH wild-type glioblastoma

Glioblastoma is the most frequently occurring and invariably fatal primary brain tumor in adults. The vast majority of glioblastomas is characterized by chromosomal copy number alterations, including gain of whole chromosome 7 and loss of whole chromosome 10. Gain of whole chromosome 7 is an early e...

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Vydáno v:Genes Dev
Hlavní autoři: Cimino, Patrick J., Kim, Youngmi, Wu, Hua-Jun, Alexander, Jes, Wirsching, Hans-Georg, Szulzewsky, Frank, Pitter, Ken, Ozawa, Tatsuya, Wang, Jiguang, Vazquez, Julio, Arora, Sonali, Rabadan, Raul, Levine, Ross, Michor, Franziska, Holland, Eric C.
Médium: Artigo
Jazyk:Inglês
Vydáno: Cold Spring Harbor Laboratory Press 2018
Témata:
Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5959235/
https://ncbi.nlm.nih.gov/pubmed/29632085
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.312157.118
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