In vivo and in vitro oncogenic effects of HIF2A mutations in pheochromocytomas and paragangliomas

Pheochromocytomas and paragangliomas are highly vascular tumors of the autonomic nervous system. Germline mutations, including those in hypoxia-related genes, occur in one-third of the cases, but somatic mutations are infrequent in these tumors. Using exome sequencing of 6 paired constitutive and tu...

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Détails bibliographiques
Publié dans:Endocr Relat Cancer
Auteurs principaux: Toledo, Rodrigo A., Qin, Yuejuan, Srikantan, Subramanya, Morales, Nicole Paes, Li, Qun, Deng, Yilun, Kim, Sang-Woo, Pereira, Maria Adelaide A., Toledo, Sergio P.A., Su, Xiaoping, Aguiar, Ricardo C. T., Dahia, Patricia L. M.
Format: Artigo
Langue:Inglês
Publié: 2013
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5944295/
https://ncbi.nlm.nih.gov/pubmed/23533246
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1530/ERC-13-0101
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