In vivo and in vitro oncogenic effects of HIF2A mutations in pheochromocytomas and paragangliomas

Pheochromocytomas and paragangliomas are highly vascular tumors of the autonomic nervous system. Germline mutations, including those in hypoxia-related genes, occur in one-third of the cases, but somatic mutations are infrequent in these tumors. Using exome sequencing of 6 paired constitutive and tu...

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Bibliographic Details
Published in:Endocr Relat Cancer
Main Authors: Toledo, Rodrigo A., Qin, Yuejuan, Srikantan, Subramanya, Morales, Nicole Paes, Li, Qun, Deng, Yilun, Kim, Sang-Woo, Pereira, Maria Adelaide A., Toledo, Sergio P.A., Su, Xiaoping, Aguiar, Ricardo C. T., Dahia, Patricia L. M.
Format: Artigo
Language:Inglês
Published: 2013
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5944295/
https://ncbi.nlm.nih.gov/pubmed/23533246
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1530/ERC-13-0101
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