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Increased activity of both CDK1 and CDK2 is necessary for the combinatorial activity of WEE1 inhibition and cytarabine

Inhibition of WEE1 is emerging as a promising chemosensitization strategy in many cancers including acute leukemia. Our lab and others have demonstrated that a small-molecule inhibitor of WEE1, AZD1775, sensitizes acute leukemia cells to cytarabine; however, a mechanism of combinatorial activity has...

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Publicat a:Leuk Res
Autors principals: Garcia, Tamara B., Fosmire, Susan P., Porter, Christopher C.
Format: Artigo
Idioma:Inglês
Publicat: 2017
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5929465/
https://ncbi.nlm.nih.gov/pubmed/29175378
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.leukres.2017.11.004
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