High Complement Factor H-Related (FHR)-3 Levels Are Associated With the Atypical Hemolytic-Uremic Syndrome-Risk Allele CFHR3*B

Dysregulation of the complement alternative pathway (AP) is a major pathogenic mechanism in atypical hemolytic-uremic syndrome (aHUS). Genetic or acquired defects in factor H (FH), the main AP regulator, are major aHUS drivers that associate with a poor prognosis. FH activity has been suggested to b...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Pouw, Richard B., Gómez Delgado, Irene, López Lera, Alberto, Rodríguez de Córdoba, Santiago, Wouters, Diana, Kuijpers, Taco W., Sánchez-Corral, Pilar
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2018
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5928496/
https://ncbi.nlm.nih.gov/pubmed/29740447
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2018.00848
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