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Pharmacological activation of REV-ERBs is lethal in cancer and oncogene induced senescence
The circadian clock imposes daily rhythms in cell proliferation, metabolism, inflammation and DNA damage response(1, 2). Perturbations of these processes are hallmarks of cancer(3) and chronic circadian rhythm disruption predisposes to tumor development(1, 4). This raises the hypothesis that pharmac...
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| Publicado no: | Nature |
|---|---|
| Main Authors: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5924733/ https://ncbi.nlm.nih.gov/pubmed/29320480 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature25170 |
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