Imidazolopiperazines Kill both Rings and Dormant Rings in Wild-Type and K13 Artemisinin-Resistant Plasmodium falciparum In Vitro

Artemisinin (ART) resistance has spread through Southeast Asia, posing a serious threat to the control and elimination of malaria. ART resistance has been associated with mutations in the Plasmodium falciparum kelch-13 (Pfk13) propeller domain. Phenotypically, ART resistance is defined as delayed pa...

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Veröffentlicht in:Antimicrob Agents Chemother
Hauptverfasser: Dembele, Laurent, Gupta, Devendra Kumar, Lim, Michelle Yi-Xiu, Ang, Xiaoman, Selva, Jeremy J., Chotivanich, Kesinee, Nguon, Chea, Dondorp, Arjen M., Bonamy, Ghislain M. C., Diagana, Thierry T., Bifani, Pablo
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2018
Schlagworte:
Mechanisms of Action: Physiological Effects
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5923180/
https://ncbi.nlm.nih.gov/pubmed/29530849
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02235-17
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