In Vitro Activity of Lascufloxacin against Streptococcus pneumoniae with Mutations in the Quinolone Resistance-Determining Regions

Lascufloxacin showed potent activity against Streptococcus pneumoniae with a GyrA or ParC mutation (first-step mutant). The frequency of selecting resistant strains tended to be lower for lascufloxacin than for levofloxacin and garenoxacin after drug exposure in first-step mutants but was similar in...

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Udgivet i:Antimicrob Agents Chemother
Main Authors: Murata, Mika, Kosai, Kosuke, Yamauchi, Shunsuke, Sasaki, Daisuke, Kaku, Norihito, Uno, Naoki, Morinaga, Yoshitomo, Hasegawa, Hiroo, Miyazaki, Taiga, Izumikawa, Koichi, Mukae, Hiroshi, Yanagihara, Katsunori
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2018
Fag:
Mechanisms of Resistance
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5913943/
https://ncbi.nlm.nih.gov/pubmed/29439959
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01971-17
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