Design and evaluation of bi- and trispecific antibodies targeting multiple filovirus glycoproteins

Filoviruses (family Filoviridae) include five ebolaviruses and Marburg virus. These pathogens cause a rapidly progressing and severe viral disease with high mortality rates (generally 30–90%). Outbreaks of filovirus disease are sporadic and, until recently, were limited to less than 500 cases. Howev...

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Dettagli Bibliografici
Pubblicato in:J Biol Chem
Autori principali: Nyakatura, Elisabeth K., Zak, Samantha E., Wec, Anna Z., Hofmann, Daniel, Shulenin, Sergey, Bakken, Russell R., Aman, M. Javad, Chandran, Kartik, Dye, John M., Lai, Jonathan R.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2018
Soggetti:
Protein Structure and Folding
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5912469/
https://ncbi.nlm.nih.gov/pubmed/29500195
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA117.001627
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