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Intermolecular interaction as a direct measure of water solubility advantage of meloxicam cocrystalized with carboxylic acids
The solubility advantage (SA) of meloxicam cocrystalized with mono- and dicarboxylic acids was expressed in terms of equilibrium constants involving active pharmaceutical ingredient and coformer in aqueous solutions. It is argued that SA can be quantified by concentration of pairs formed in water. T...
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| Publicado no: | J Mol Model |
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| Autor principal: | |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Springer Berlin Heidelberg
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5911280/ https://ncbi.nlm.nih.gov/pubmed/29680958 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00894-018-3649-0 |
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