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Synergistic interaction between a PDE5 inhibitor (sildenafil) and a new adenosine A(2A) receptor agonist (LASSBio-1359) improves pulmonary hypertension in rats
INTRODUCTION: Pulmonary hypertension (PH) is characterized by enhanced pulmonary vascular resistance, which causes right ventricle (RV) pressure overload and results in right sided heart failure and death. This work investigated the effectiveness of a combined therapy with PDE5 inhibitor (PDE5i) and...
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| Wydane w: | PLoS One |
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| Główni autorzy: | , , , , , , , , |
| Format: | Artigo |
| Język: | Inglês |
| Wydane: |
Public Library of Science
2018
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| Hasła przedmiotowe: | |
| Dostęp online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5909907/ https://ncbi.nlm.nih.gov/pubmed/29677206 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0195047 |
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