Neuromodulatory Effect of Thymoquinone in Attenuating Glutamate-Mediated Neurotoxicity Targeting the Amyloidogenic and Apoptotic Pathways

Overexposure of the glutamatergic N-methyl-d-aspartate (NMDA) receptor to the excitatory neurotransmitter l-glutamic acid leads to neuronal cell death by excitotoxicity as a result of increased intracellular Ca(2+), mitochondrial dysfunction, and apoptosis. Moreover, it was previously reported that...

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Detalhes bibliográficos
Publicado no:Front Neurol
Main Authors: Fouad, Ibram Amin, Sharaf, Nadia Mohamed, Abdelghany, Ragwa Mansour, El Sayed, Nesrine Salah El Dine
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2018
Assuntos:
Neuroscience
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5908889/
https://ncbi.nlm.nih.gov/pubmed/29706929
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fneur.2018.00236
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