The CPT1a inhibitor, etomoxir induces severe oxidative stress at commonly used concentrations

Etomoxir (ETO) is a widely used small-molecule inhibitor of fatty acid oxidation (FAO) through its irreversible inhibitory effects on the carnitine palmitoyl-transferase 1a (CPT1a). We used this compound to evaluate the role of fatty acid oxidation in rapidly proliferating T cells following costimul...

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Veröffentlicht in:Sci Rep
Hauptverfasser: O’Connor, Roddy S., Guo, Lili, Ghassemi, Saba, Snyder, Nathaniel W., Worth, Andrew J., Weng, Liwei, Kam, Yoonseok, Philipson, Benjamin, Trefely, Sophie, Nunez-Cruz, Selene, Blair, Ian A., June, Carl H., Milone, Michael C.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2018
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5908836/
https://ncbi.nlm.nih.gov/pubmed/29674640
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-24676-6
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