Macromolecular Crowding May Significantly Affect the Performance of an MRI Contrast Agent: A (1)H NMR Spectroscopy, Microimaging, and Fast‐Field‐Cycling NMR Relaxometry Study

Contrast enhancement agents are often employed in magnetic resonance imaging (MRI) for clinical diagnosis and biomedical research. However, the current theory on MRI contrast generation does not consider the ubiquitous presence of macromolecular crowders in biological systems, which poses the risk o...

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Bibliographic Details
Published in:ChemistryOpen
Main Authors: Cheng, Ren‐Hao, Chen, Jie‐Min, Chen, Yu‐Wen, Cai, Honghao, Cui, Xiaohong, Hwang, Dennis W., Chen, Zhong, Ding, Shangwu
Format: Artigo
Language:Inglês
Published: John Wiley and Sons Inc. 2018
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5891664/
https://ncbi.nlm.nih.gov/pubmed/29657915
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/open.201700192
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