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S100A4 blockage alleviates agonistic anti-CD137 antibody-induced liver pathology without disruption of antitumor immunity
Liver-related autoimmune toxicities triggered by agonistic anti-CD137 antibodies have greatly limited their use in clinical applications. Here, we found that anti-CD137 monoclonal antibody (mAb) treatment in mice induced the infiltration of a large number of S100A4(+) macrophages into the liver. Dep...
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| Udgivet i: | Oncoimmunology |
|---|---|
| Main Authors: | , , , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Taylor & Francis
2018
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5889198/ https://ncbi.nlm.nih.gov/pubmed/29632708 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/2162402X.2017.1296996 |
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