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Changes in Sensitivity to the Effects of Atrazine on the Luteinizing Hormone Surge in Female Sprague-Dawley Rats after Repeated Daily Doses: Correlation with Liver Enzyme Expression

BACKGROUND: Atrazine suppression of the LH surge slowly develops over time and peaks after 4 days; sensitivity to atrazine decreases after 8 or 14 days of dosing. Adaptation of the LH response was correlated with increased phase I and phase II liver enzyme activity/expression. METHODS: The effect of...

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Publicat a:Birth Defects Res
Autors principals: Breckenridge, Charles B., Foradori, Chad D., Coder, Pragati Sawhney, Simpkins, James W., Sielken, Robert L., Handa, Robert J.
Format: Artigo
Idioma:Inglês
Publicat: 2017
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5884089/
https://ncbi.nlm.nih.gov/pubmed/29134775
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/bdr2.1130
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