A GATA3-specific DNAzyme attenuates sputum eosinophilia in eosinophilic COPD patients: a feasibility randomized clinical trial

BACKGROUND: A subset of COPD-patients presents with eosinophilic airway inflammation. While treatment of asthmatic patients with the GATA3-specific DNAzyme SB010 attenuated sputum eosinophilia after allergen challenge, this specific treatment has not been evaluated in patients with COPD. Our objecti...

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Pubblicato in:Respir Res
Autori principali: Greulich, Timm, Hohlfeld, Jens M., Neuser, Petra, Lueer, Katrin, Klemmer, Andreas, Schade-Brittinger, Carmen, Harnisch, Susanne, Garn, Holger, Renz, Harald, Homburg, Ursula, Renz, Jonas, Kirsten, Anne, Pedersen, Frauke, Müller, Meike, Vogelmeier, Claus F., Watz, Henrik
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2018
Soggetti:
Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5883532/
https://ncbi.nlm.nih.gov/pubmed/29615049
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12931-018-0751-x
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