Endothelial indoleamine 2,3-dioxygenase-1 regulates the placental vascular tone and is deficient in intrauterine growth restriction and pre-eclampsia

Indoleamine 2,3-dioxygenase-1 (IDO1) mediates the degradation of L-tryptophan (L-Trp) and is constitutively expressed in the chorionic vascular endothelium of the human placenta with highest levels in the microvasculature. Given that endothelial expression of IDO1 has been shown to regulate vascular...

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Pubblicato in:Sci Rep
Autori principali: Zardoya-Laguardia, Pablo, Blaschitz, Astrid, Hirschmugl, Birgit, Lang, Ingrid, Herzog, Sereina A., Nikitina, Liudmila, Gauster, Martin, Häusler, Martin, Cervar-Zivkovic, Mila, Karpf, Eva, Maghzal, Ghassan J., Stanley, Chris P., Stocker, Roland, Wadsack, Christian, Frank, Saša, Sedlmayr, Peter
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2018
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5883010/
https://ncbi.nlm.nih.gov/pubmed/29615752
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-23896-0
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