The truncated mutant HBsAg expression increases the tumorigenesis of hepatitis B virus by regulating TGF-β/Smad signaling pathway

BACKGROUND: It has been reported that the emergence of HBV rtA181T/sW172* mutant could result in a dominant secretion defect of HBsAg and increase the risk of HCC development. This study was designed to reveal the role and possible pathogenic mechanism of truncated mutant HBsAg in tumorigenesis of H...

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Bibliografiske detaljer
Udgivet i:Virol J
Main Authors: Wang, Meng-Lan, Wu, Dong-Bo, Tao, Ya-Chao, Chen, Lan-Lan, Liu, Cui-Ping, Chen, En-Qiang, Tang, Hong
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2018
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5879756/
https://ncbi.nlm.nih.gov/pubmed/29609638
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12985-018-0972-0
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