CD47 Blockade Reduces Ischemia/Reperfusion Injury in Donation after Cardiac Death Rat Kidney Transplantation

Modulation of nitric oxide (NO) activity through blockade of CD47 signaling has been shown to reduce ischemia-reperfusion injury (IRI) in various models of tissue ischemia. Here, we evaluate the potential effect of an antibody-mediated CD47 blockade in a syngeneic and an allogeneic DCD rat kidney tr...

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Pubblicato in:Am J Transplant
Autori principali: Wang, Xuanchuan, Xu, Min, Jia, Jianluo, Zhang, Zhengyan, Gaut, Joseph P., Upadhya, Gundumi A., Manning, Pamela T., Lin, Yiing, Chapman, William C.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2017
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5878706/
https://ncbi.nlm.nih.gov/pubmed/28975767
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/ajt.14523
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