Anti-CD47 Monoclonal Antibody Therapy Reduces Ischemia-Reperfusion Injury of Renal Allografts in a Porcine Model of Donation after Cardiac Death

We investigated whether blockade of the CD47 signaling pathway could reduce ischemia-reperfusion injury (IRI) of renal allografts donated after cardiac death (DCD) in a porcine animal model of transplantation. Renal allografts were subjected to 30 min of warm ischemia, 3.5 hours of cold ischemia and...

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Détails bibliographiques
Publié dans:Am J Transplant
Auteurs principaux: Xu, Min, Wang, Xuanchuan, Banan, Babak, Chirumbole, Danielle L., Garcia-Aroz, Sandra, Balakrishnan, Aparna, Nayak, Deepak K., Zhang, Zhengyan, Jia, Jianluo, Upadhya, Gundumi A., Gaut, Joseph P., Hiebsch, Ronald, Manning, Pamela T., Wu, Ningying, Lin, Yiing, Chapman, William C.
Format: Artigo
Langue:Inglês
Publié: 2017
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5878700/
https://ncbi.nlm.nih.gov/pubmed/29087049
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/ajt.14567
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